The antihistamine question in gut-brain disorders
01 · The Practice“My doctor mentioned taking Claritin and Pepcid together for my stomach. Is that crazy?” It is not crazy. It is also not a cure. The reasoning is more interesting than the pills.
Your gut wall is packed with the same immune cells that fire during an allergic reaction. When they crowd the nerves, they turn up the volume on signals the brain reads as pain. Block that signal, and in small studies, the volume comes down.